Pharsight's "computer-assisted trial design" system models and simulates clinical trials to determine the optimal number of patients, dose amounts, and dosing frequency, all of which have for years mostly been determined through time-consuming and costly trial and error.
In a traditional system capacity studies, the pdf of the SIR has been determined through time-consuming Monte Carlo simulation or by only accounting for either the large-scale path loss [2] or multipath propagations [3], which are incomplete for studying realistic system deployment scenarios.
Aerosol concentration vs. time profiles, determined through real-time laser diffraction particle sizing, demonstrated that the majority of the powder from RH was emitted within one second while a more prolonged aerosolisation was observed from MI and HH.
The neutron energy and prompt-photon discrimination is determined through the time of flight technique.
In this respect a pseudo-stable manifold (SM) is initially determined through backward time integration of the bicircular four body (BCFB) equations of motion, whose initial states are obtained via stable manifolds of the restricted three body problem (R3BP).
If a match in the knock-out stages ends in a draw, the winner is determined through extra time.
Using the UK general population preference weights determined through the time trade off approach [ 36], utilities ranging from −0.59 to 1 can be attached to each of the health states with a higher utilities implying better quality of life.
The choice of using different dyes at various time points during the experiment in cells, when protein translation is not inhibited, will lead to distinct populations of otherwise identical proteins whose discriminating features are determined through the time point of the respective labeling of each population.
Further, the above theoretical results are also compared with those determined through a time-domain criterion proposed in the past by some of the present authors.
In order to validate the array-CGH results, gene dosage of several putative candidates was determined through real-time PCR quantification of mutant/wild type signals for candidate ESTs as related to a reference undeleted gene [GenBank: CX293764].
