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To understand the properties of S4 subsite structurally, we determined the structures of wt GlpG and its F146I mutant complexed to Ac-FATA-cmk (2.9 and 2.55 Å resolution, respectively, Supplementary Table S1) and compared the ligand-binding mode to the parent structure of GlpG and Ac-IATA-cmk complex.
We recently developed a software package for symmetry-mismatch structural reconstruction and determined the structures of the genome and RNA polymerases within an icosahedral virus for the first time.
To further characterize the structural impact of covalent modifications at Cys84 on CaS100B, we next determined the structures of the S100B complexes with each compound by X-ray crystallography.
We've determined the structures of five different potassium channels now.
We have determined the structures of several TRPV channel cytosolic domains.
We determined the structures of compounds 6 and 9 by interpreting the spectroscopic data (1D/2D NMR and MS).
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That same year, James Watson and Francis Crick determined the structure of DNA.
In 1963, they determined the structure of CBD.
So Dr. Lawrence Shapiro and colleagues at the Mount Sinai School of Medicine determined the structure of the Tubby protein.
That began a phantasmagoria of events that has since determined the structure of our lives.
And in January 1952, Dr. Pauling indeed announced that he had determined the structure of DNA.
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