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Steric factors also determined the selectivity of scaffold types produced, with larger groups producing predominantly alkene products.
As a first step towards the optimization of the fractionation process, the composition of the co-solvent used in the supercritical phase was studied by considering different ethanol:water mixtures, which undoubtedly determined the selectivity of the extraction process.
In the second part of the evaluation, we determined the selectivity of the amplicons.
As a direct measure of the enzyme's ability to discriminate between the natural dATP substrate and the TFV, we determined the "selectivity", defined as the ratio of efficiency of the enzyme to incorporate dATP over TFV-DP (kpol-dATP/KD-dATP/kpol-TFV/KD-TFV).
We first determined the selectivity of these two molecules towards Hdacs1,2.
We determined the selectivity of TAK-242 against the TLR family and its efficacy in vitro and in vivo.
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To determine the selectivity of the responses we observed in face-selective regions, we measured the peak response in an early visual region for each condition in Experiments 2 and 3.
The ratio of protonated to acylated surface centres strongly determines the selectivity.
Complex structures with adenosine and AMPCP indicate that structural control of the domain movement determines the selectivity for monophosphate nucleotides.
It is shown experimentally that the shape and size of the cavity determines the selectivity of separation.
Major challenges facing the field include understanding of the factors determining the selectivity of kinase inhibitors and the development of compounds with the desired selectivity profile.
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