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Because Akt signalling is an important pathway controlling cell survival [45] and cross talks between Wnt and Akt signalling have been reported in osteoblasts [9], [24], [46], we determined the implication of Akt in the altered cell survival induced by N-cadherin-LRP5 interaction in osteoblasts.
In addition, we have determined the implication of specific regions of C2-L1Tc in the nucleic-acid-binding properties of the protein and its relationship to the NAC activity.
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Using 4854 asymptomatic participants from the population-based Rotterdam Study, we determined the implications of the new ACC/AHA guideline's treatment threshold and risk prediction model and compared it with the Adult Treatment Panel III (ATP-III), and the European Society of Cardiology ESCC) guidelines.
Notice that this specification is not neutral in determining the implication of taxes for hours worked.
Different approaches were used to determine the implication of the R1 and R2 regions in RNA binding, plasmodesmata (PD) targeting and cell-to-cell movement.
Therefore, there is need to determine the implication of the transforming urban landscapes on urban micro-climate to optimise urban land uses and to effectively mitigate adverse impacts.
Tests for anxiety in rodents are suggested to be valuable tools in determining the implication of genetic factors within the whole complexity of behavior and are specifically valuable in identifying the profile of anxiety-related behavior in these animals.
To further determine the implication of Wnt signalling, cells were treated with Wnt3a (15% CM) and the protein levels of Bax and Bcl-2 were determined.
We then sought to determine the implication of canonical Wnt signalling in the altered ERK and PI3K signalling induced by N-cadherin-LRP5 interaction.
Lithium chloride (LiCl), a selective inhibitor of GSK-3β [38], was used to determine the implication of GSK-3β in MPP+-induced neuronal cell death.
To determine the implication of oxidative stress per se in alterations in mitochondrial functions, Caco-2/15 cells were incubated with FE/ASC (0.2 mM/2 mM) for 6 h alone and/or with the antioxidant butylated hydoxytoluene (BHT) (2,6-di-t-butyl-p-cresol, Sigma, St-Louis, MA) (50 µM).
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