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We followed Fe-S assembly directly in yeast cells by 55Fe radiolabeling and determined the consequence of the cysteine mutations on S phase progression and pol-prim loading at early replication origins by chromatin immunoprecipitation (ChIP).
Since TBK1 and TRAF6 compete to bind to the N-terminal domain of TRIF [21], we determined the consequence of removing TRAF6 molecules on the TRAM-dependent pathway.
To investigate the putative effects of miR-15b, miR-16, miR-20a, and miR-20b, we determined the consequence of over-expressing these miRNAs on VEGF expression.
To validate the plate-based method, we determined the consequence of manipulating Imd pathway signaling for Bsk phosphorylation.
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We first determined the consequences of expressing the PyMT-IRES-Luc transgene exclusively in β cells of the pancreas.
We next determined the consequences of the increased lymphatic vessel density in ACKR2-deficient mice.
To investigate the in vivo role of Trap1 in Drosophila, we first determined the consequences of its loss.
To address this question, we determined the consequences of reducing endogenous WLS in a xenograft model of melanoma.
To test the hypothesis that activation of Nrf2 provides skin protection under stress conditions, we determined the consequences of pharmacological or genetic activation of Nrf2 in keratinocytes.
To understand the homeostatic function of enhanced sterol synthesis, we determined the consequences of inhibiting sterol metabolism in HeLa cells that express wild-type and mutant neuroserpin.
If such relationships were to be determined, "the consequences of long-term exposure to traffic noise may be of even greater importance than previously anticipated," Eriksson says.
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