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These results support the suggestion that an environmental manipulation such as a long-term exposure to a sucrose-fading procedure did not overcome the genetically determined predisposition to avoid ethanol in sNP rats.
The question arises of whether a genetically determined predisposition alone may explain the early onset of cardiac involvement in the CAD group.
However, more individuals than expected by chance showed consistent behaviour among years, thus suggesting some genetically determined predisposition, as found in other birds (e.g., Pulido et al. 1996).
Besides the complex pathophysiologic interactions within inflammatory cascade and coagulation, a genetically determined predisposition for sepsis and septic shock is another reason that diverts the clinical course of sepsis and septic shock from one that is linearly predictable.
38 In this respect, Tavani et al 39 have previously examined the joint effect of a family history of heart disease, taken as a proxy for genetically determined predisposition to the disease, and selected adult life risk factors on the risk of the disease and have shown that a substantial increase in heart disease is evident when a family history and the environmental risk factors are present.
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In contrast, relatively few studies have investigated the role of genetic variation in humans in determining predisposition and clinical severity.
Personalized medicine allows an individual to have a panel of genetic tests performed to determine predisposition to disease.
15, 16 Moreover, overexpression of the B1 receptor in adipocytes demonstrated that this receptor regulates glucose tolerance and determines predisposition to obesity.
Current research on host polymorphisms in inflammatory response genes supports the role of host genetics in determining predisposition to gastric cancer (GC).
Blood clot formation represents the last step in the athero-thrombotic process, and the structure of the fibrin network has a role in determining predisposition to cardiovascular disease.
One of the most exciting discoveries of the last 5 years has been the discovery of the important role of DNA copy number variations or polymorphisms (CNVs) in determining predisposition to diseases such as autism, HIV infection and glomerulonephritis [ 1- 4].
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