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The observed frequencies of the mutations in this series of patients are similar to the frequencies of the 737 CRC cases, including the rectosigmoid cancer cases, for whom K-ras mutation status was determined (Brink et al, 2003).
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See Brink (1994) for an alternative view.
Technically speaking, Dell appears determined to claws its way back from the brink.
In the Cavendish Pairs in Las Vegas a week ago, Marty Fleisher, 41, a Manhattan lawyer, was on the brink of his first big victory and determined to avoid error.
"'Tail', for example, is tangled and inert and teeters precariously on the brink of disappearing up its own arsehole, but a determined listener will find its hooks more infecting with each spin".
A nation at risk - Libya is at the brink of a civil war, but its citizens are more determined than ever for change, according to Hisham Matar in the New Yorker.
We stood at the brink of a "small war". An uncompromising President Bill Clinton was determined to strike Iraq to avoid the deadly aggression of Saddam Hussein.
United's form seemed to leave Van Gaal on the brink over the Christmas period, but Woodward is believed to be determined to see the former Ajax and Barcelona manager succeed.
Needing to jump in somewhere, we determined that a structured, substantive conversation would be in order, among people who live comfortably on the brink of the millennium both fascinated and troubled by the stage of technology in which we are currently stuck.
But the 1962 crisis shows that a small, determined revolutionary state, backed into a corner and convinced of its inevitable demise, can bring the world to the brink of catastrophe.
He had been a member of the Afghan security forces for several years.Thirteen years after the international invasion, on the brink of a transition that will determine Afghanistan's future, suspicions between the two sides run deep.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com