However, enrichment analysis of an independent set of experimentally determined annotations, the MGI mouse phenotypes, highlighted the same biological processes, thus validating the GO results.
We have compared the GO term enrichment of proteins with experimentally determined annotations obtained at the start of the initiative with annotations currently available.
All of these approaches rely upon additional information to determine annotation quality.
It can help researchers determine annotation sample size for supervised machine learning.
The community lacks a generic measure for determining annotation quality and correctness, which we look at addressing within this article.
The method of the Exome Sequencing Project was not developed to utilize the combination of multiple variant-callers, and it determines annotation value cutoffs for defining negative training examples and gold standard data sets for defining positive training examples [ 14].
The NCBI database Gene [ 10] was used to determine annotations for the rhesus draft genome.
Genomes were also compared for the presence or absence of Pfam domain annotations to determine annotations that are specific to one or two of the six completely sequenced strains of R. palustris.
Many methods have been developed for determining annotations computationally such as categorizing gene expression patterns (e.g Zhou and Peng, 2007) or predicting cell identities (e.g. Long et al., 2008a).
We narrowed our annotation to 35 ORFs by comparison with previously determined adenoviral annotations, but we consider our annotation provisional.
