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Objectives: A pilot study was designed to analyze lymphoid cell infiltration in Epstein-Barr virus positive (EBV+) nasopharyngeal carcinomas (NPCs) and to determine whether this pattern of infiltration is consistent with non-EBV+ head and neck carcinomas or with solid EBV+ tumors in other locations.
We next sought to determine whether this pattern would also be observed in early visual areas.
To determine whether this pattern of drug-resistance mutations was common to other XDR strains from KZN, we sequenced eight additional strains fitting the XDR profile, including clinical isolates obtained from other sites in the KZN region: TF274, R257, R503, R262, R299, TF275, R376, and TF490 (the three 'TF' strains were obtained from Tugela Ferry, approximately 60 miles north of Durban).
Longer time to evaluate will allow us to determine whether this pattern holds beyond 2 years.
Further work is now required to determine whether this pattern of activation represents a general mechanism for signalling by plexin receptors, and for the inhibition of Rap.
We have begun investigating levels of introgression at field sites where D. carinulata has failed to establish to determine whether this pattern holds true.
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Next, we determined whether this pattern would be reflected in tumor growth of PC3 xenografts.
It will be of great interest to further enhance our understanding of how this mechanism works and affects other dimerizing TF families, like the bHLH and nuclear receptors, determining whether this pattern is global or restricted to the bZIPs.
We are unaware of any study that tried to determine whether this fluctuating pattern occurred on daily, weekly, monthly, or yearly basis.
To determine whether this induction pattern is sustained throughout tumorigenesis, we performed real-time RT PCR analysis of NKD1 and FZD3 in a series of 23 colorectal cancers.
In addition, longer term longitudinal use of EHRs for this type of surveillance can determine whether the pattern observed one season is repeated the next.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com