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To determine whether the specificity was constant as a function of month and year, we performed similar chi-square analyses after tallying alarm days by month of the year and by calendar year of the study, respectively.
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Future investigation is necessary to determine whether the substrate specificity of ACOX2-i9 is different from that of canonical ACOX2.
Our aim was to determine whether the apparent specificity of this new approach is gained at the expense of decreased sensitivity.
To determine whether the antigen specificity of liver-infiltrating Tregs is affected by IDLV.142T administration, the antigen-driven conversion of naive CD4+FOXP3− T cells into FOXP3+ Tregs was evaluated.
To address this, we mated a γδTCR transgene onto Lck+/− and Fyn+/− genetic backgrounds to determine whether fixing the specificity of the γδTCR revealed defects in αβ/γδ lineage choice and/or γδ T cell development.
To determine whether the cell-type specificity was preserved in bidirectional promoters, we performed immunohistochemical staining with antibodies against the neuron-specific nuclear protein (NeuN) to visualize neurons and antibodies against the glial fibrillary acidic protein (GFAP) to visualize astrocytes.
However, further work is needed to determine whether the sensitivity and specificity of this method are sufficient for clinical application, as a tool for analysis of different kinds of crepitus which are the result of impairment of joint motion quality.
We tested the activity of Lpa against the three lipoylated proteins found in E. coli (the H-protein of the glycine cleavage complex and the E2 subunits of pyruvate dehydrogenase and alpha-ketoglutarate dehydrogenase) to determine whether the enzyme has a broad specificity for lipoylated proteins.
In order to determine whether the mutation changed the substrate specificity of the enzyme, we tested the P2 P4 sites in the V266E mutants using a positional scanning peptide library containing an aspartate residue fixed in the P1 position.
These isolates represented the isolate diversity in California, and they were used to determine whether the detected QTL showed isolate-specificity.
To determine whether the decrease in read depth affects specificity, we also estimate the false discovery proportion (FDP) at each depth.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com