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First, data visualization and modeling techniques were employed to determine unbiased effect size estimates unaffected by ceiling effects, skewed standard deviations, and other distribution problems that are widespread in prospective memory research [15], [16].
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In fact, the variability of oilsands, in terms of both quality and composition, makes it difficult to determine the unbiased effect of any individual component on bitumen extraction from mined ore.
Stereologic methods were employed to determine an unbiased estimate of total neurons and tyrosine hydroxylase (TH) immunopositive and Nissl-stained neurons within SNpc.
The Multistate Bennett Acceptance Ratio (MBAR) method [21], a statistically optimal variant of the Weighted Histogram Analysis Method (WHAM) [22], is used to determine the unbiased average values of thermodynamic properties such as energies and conformational entropies as a function of the RMSD.
Additionally probes were randomly selected for sequencing to determine an unbiased confirmation rate.
The objective of most biomedical research is to determine an unbiased estimate of effect for an exposure on an outcome, i.e. to make causal inferences about the exposure.
We carried out a population-based study to determine the unbiased, age-specific Plasmodium falciparum prevalence, asexual and sexual parasite density, and spatial distribution to establish rates of infection at a site in western Kenya.
The magnitude of the deficits in a battery of behavioral tests designed to assess striatal function was highly correlated to the extent of ischemic damage determined by unbiased stereological estimations of striatal neuron numbers.
However, determining an unbiased objective function in a eukaryotic system is often difficult.
Occasionally, selected morphological features are recorded and the content of key chemical constituents determined, but unbiased and comprehensive chemical phenotypes have not been included systematically in diversity surveys.
The load of Th-S and 3D12 immunopositive amyloid plaques in the neocortex and hippocampus was determined using unbiased sampling and automated image threshold analysis, as previously described [ 13, 15].
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