Exact(5)
"Using keywords to determine targeting on content pages is really fallible," he says.
Cytotoxicity was used to determine targeting selectivity of the designed carriers in vitro by utilizing KB cells expressing both FR and EGFR and off-target control cells in which one or both receptors were blocked.
We then used siRNA knockdown of AP1B (μ1B) to determine targeting of prestin YFP in MDCK cells.
However, the overlap between highly mutated promoters by both AID and APOBEC3G suggests that rather than conservation of protein protein interactions of the deaminases with the transcription complex, properties of the promoter itself can determine targeting.
Furthermore when assessing targeting, prediction and phylogenetic comparisons provides additional avenues to assess targeting, and along with GFP tagging, can be used to determine targeting ability of proteins in a variety of plant species, where direct biochemical approaches with gene families are not feasible.
Similar(55)
In eukaryotic genomes, it is challenging to accurately determine target sites of transcription factors (TFs) by only using sequence information.
The former MP for Solihull Lorely Burt, and her counterpart in Cheltenham, Martin Horwood, were high-profile casualties of the determined, targeted attack by their former coalition partners.
In climate science, the target is used as the basis for complex calculations, especially to determine target-compatible carbon budgets and emissions reduction paths.
Solution techniques to determine targets are relatively simple and time-efficient even for large-scale problems.
Several approaches employ molecular docking to determine target-specific thresholds that can be used as filters in virtual screening.
SAR signal processing methods are then used to generate range and cross-range profiles which determine target position.
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