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Another technique, nuclear magnetic resonance, can determine structures of proteins in solution, without the need for crystals.
This instrument is also the direct ancestor of equipment housed at the massive Diamond light source now used to determine structures of biological molecules, so giving insights into the workings of life.
Density Functional Theory (DFT) calculations were used to determine structures, gas phase acidities and pKa values for the new dyes.
We define a SPOP-binding consensus (SBC) and determine structures revealing recognition of SBCs from the phosphatase Puc, the transcriptional regulator Ci, and the chromatin component MacroH2A.
For example, organizational policies clearly influence (and in some cases determine) structures, while existing structures, force levels and types have an influence on policies that are developed and implemented regarding their utilization.
The advent of direct electron detectors has enabled the routine use of single-particle cryo-electron microscopy (EM) approaches to determine structures of a variety of protein complexes at near-atomic resolution.
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X-ray laser – used to determine structure of an enzyme required by the parasite that causes African sleeping sickness.
Spectral analysis and X-ray crystallographic techniques have been used to determine structure of the compound.
THESEUS does not attempt to determine structure-based sequence alignments, which is a distinct bioinformatics problem (Bourne and Weissig, 2003).
Some scientists oppose the public project, saying that blindly determining structures, rather than working on proteins of known interest, is neither useful nor intellectually challenging.
They exploit the vast amount of experimentally determined structures to derive statistical atom pair potentials.
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