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Several bioinformatic resources were used to determine regulatory elements present in the core and proximal promoter regions of Lim3A and Lim3C.
MRNet is applied to determine regulatory targets and pathways.
This approach has been applied to determine regulatory network for yeast [ 155].
Transcriptome profiles across a diverse set of conditions can be used to systematically determine regulatory interactions [ 4].
Therefore, to minimise the risk of circularity in our analysis, we have used separate datasets to determine cooperative gene interactions, and to determine regulatory targets.
The mouse is the principal model organism used to determine regulatory mechanisms operating to control thymus development and function, and therefore interrogation of its utility for predicting mechanisms that control these processes in the human is essential.
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Little is known about the roles individual nucleotides play in mRNA target selection, in determining regulatory mechanism, or in defining Qrr potency and dynamics of target regulation.
One standard view (call it the simple technocratic view) argues that popular fear should play no role in determining regulatory choice; instead, regulators should focus on minimizing or achieving technologically feasible or cost-justified reductions in death, illness and injury.
A UTR-swap experiment was performed to identify which UTR determines regulatory direction.
Two distinct modeling approaches i) Modeling by deterministic ODEs and ii) stochastic CA-based (cellular automation) models that determines regulatory pathways from experiments exist in the literature.
It could be argued, for example, that determining regulatory interactions between pairs of regulators is a more important problem than resolving other regulatory interactions, as interactions between regulators are key to the cell's ability to process and integrate information.
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