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The results must be assessed statistically to determine linkage.
Transient outward K+current (Ito) and action potential duration (APD) were studied in 2-, 4-, 8-, and 9- to 12-month-old mice to determine linkage to ventricular remodeling (VR), ER, and heart failure (HF).
OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes.
For association mapping filtered sites within OsHKT genes were used to determine linkage disequilibrium (LD) by correlation between alleles at two loci in TASSEL 5.0 (Bradbury et al. 2007) software and significance of LD among SNPs was determined by Fisher's exact test.
The Haploview v.3.3 software [30] was used to generate haplotypes, perform haplotype association analysis, and to determine linkage disequilibrium (LD) measures (r2) between the polymorphisms.
As with previous linkage assessments in observational studies [35], our protocol (Figure 1 and Table 4) included an evaluation of sequence data from env and gag for monophyly in maximum likelihood trees to determine linkage.
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We also quantified DNA band intensities to determine linkages as unitless linkage values (ULVs) (see Methods).
A total of six candidate genes of four important QTL regions, including the cloned gene (NAL1), were identified by determining linkage disequilibrium blocks associated with significant SNPs, and haplotype analyses.
More research is needed to understand barriers former inmates face getting linked to care in the community and the role co-morbidities play in determining linkage to care and treatment uptake.
Physical distance between genes is one of the most important parameters determining linkage.
We determined linkage by counting completely associated markers within a bin of contiguous markers.
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