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Two microbicides are in phase-III clinical trials (to determine efficacy) in Africa, and four others are expected to start in the next few months.In this section The end of the beginning?
Further development for use in this patient population may require additional testing to determine efficacy in the context of the severely altered EEG patterns that are commonly observed in this group [38].
The trial was not designed or powered to determine efficacy in any specific organ system.
The β-lactam antibiotic, Ceftriaxone, began stage 3 clinical trials in May 2009 to determine efficacy in reducing excitotoxicity and neurodegeneration in ALS.
The primary objective was to determine efficacy in terms of changes in blood cholesterol in studies lasting 12 weeks or longer, that reflect the probable lifetime use of these drugs once a prescription has been written.
We have not determined what accounts for this finding, but we recognize that multiple properties beyond the interaction of the agent with the target site(s) determine efficacy in animal models.
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Determining efficacy in complementary medicine research requires valid placebo/sham control groups that are credible to patients and ensure successful blinding.
For example, dose of LMWH has been shown to be of critical importance in determining efficacy in cancer patients undergoing abdominal surgery (Carr and Rabinowitz, 2000).
A more extensive trial is required, with valid biomarkers/endpoints [91], to determine efficacy of EPO in acute kidney injury.
A more extensive trial is required, with valid biomarkers/endpoints [ 91], to determine efficacy of EPO in acute kidney injury.
To determine efficacy and safety of asoprisnil in patients with leiomyomata.
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