Sentence examples for determine downstream from inspiring English sources
Based upon the above findings, we set out to further determine downstream pathways and the role of the involved key signaling molecules in NRP-1-mediated EC survival.
Thus, we work with an aggregate autocrine FGF concentration, [FGF∗] to determine downstream receptor activity.
To determine downstream effector molecules of the PI3K pathway, we evaluated the activation of Akt by western blotting.
Different TLRs use different combinations of adaptor proteins to determine downstream signaling; TLR4 is the only known TLR that uses all these adaptor proteins.
As mentioned in the Methods section, transcription factor-DNA binding data by itself is similarly insufficient to determine downstream functional targets of a transcription factor due to the occurring nonfunctional and/or non-specific protein binding activity [ 27].
To determine downstream gene targets of P4, we established short term in vitro cultures of non-neoplastic OSE cells from six subjects, exposed the cells to P4 (10-6 M) for five days and performed transcriptional profiling with oligonucleotide microarrays containing over 22,000 transcripts.
At ID21 beamline, ESRF, the set-up is based on a lens-less approach, which accommodates a millimetric beam and spatial resolutions (determined downstream the sample by the collecting optics and the camera) ranging from 0.3 to 1.4 μm and fields of view from 600 μm up to 2 mm (cf. experimental section).
However, our ability to do so was fairly limited, compounded by well-known issues in determining downstream effects of research outputs and the integration of different citation databases.
Their specific regulation determines downstream protein-protein interactions and confers specificity on growth factor signalling.
However, both ERK and JNK were not stimulated by AA, suggesting a cell-specific role of AA in determining downstream targets.
The LDL receptor binding site is determined downstream of the B48 stop codon, as determined by an R3500Q mutation in B100 that decreases LDL particle affinity for its receptor [ 93].
