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As we wished to determine a proof of principle (i.e., our methodology would be able to detect the effect of a maternal treatment on fetal vascular reactivity), we increased the dosage of SC to maximize the chances of seeing altered abdominal aorta arterial function; SC dosage was increased to 0.8 mg/ml SC in drinking water using the same E12.5 to E18.5 dosing regimen, as previously observed (6).
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Based on our previous studies with IL-15, and to examine the efficacy of IL-15 in a clinically relevant manner, we sought to determine as a proof-of-concept if IL-15 could synergize with CpG to enhance CD8+ T-cell responses.
More exactly, while it is true that, if a formula is valid, one can eventually find a proof of it in the logic, there is in general no proof theoretic way to determine that a formula is invalid.
Due to the variability of physiological systems a flow phantom was used as a proof-of-concept for determining pressure differentials using control volume analysis [ 2].
Results of phantom experiments show agreement (12.5% normalized rms deviation) between control volume derived and directly measured pressure differential in vitro which serves as a proof-of-concept for determining in vivo pressure differentials non-invasively using control volume analysis and flow-sensitive magnetic resonance imaging.
To conduct a proof-of-concept study to determine the potential utility of a novel, adjustable single-visit, disposable device to facilitate rapid adult circumcision.
We therefore designed a proof-of-principle study to determine whether complement activation might be detectable in APS by first exposing plasmas to phospholipid vesicles.
This was a proof-of-concept study to determine the effect of MEM 1414 on allergen induced responses in mild asthmatics.
We have performed a proof-of-concept study to determine whether it might be feasible for untrained individuals to use this novel device to perform OGTTs in a community setting.
We conducted a proof-of-concept study to determine whether two of the cardinal signs of disease activity in arthritis (swelling and warmth) can be reliably quantified using existing three-dimensional (3D) and thermal digital imaging devices.
This study was designed as a proof-of-concept experiment to determine oral doses to be used in a larger investigation focusing on the potential effects of these chemicals on mammary tissue gene expression; therefore, only female Sprague-Dawley (S-D) rats were used for this study.
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