The authors should determine: A) Is the defect is also transient in the Sema3f KO ?
Objective: To determine whether a defect in energy metabolism exists in infants with cystic fibrosis (CF).
The objective of this study was to determine when a defect (hair) in a food (mushrooms) is visible to a consumer by testing the visual acuity of a consumer panel under controlled laboratory conditions.
Braswell said he asked for an investigation at the time of the crash but was told that the vehicle was too badly damaged to determine whether a defect or malfunction might have led to the accident.
"I think the car accelerated and Sage couldn't handle it". After Toyota recalled some of its models for acceleration issues, the teen's parents asked the National Highway Traffic Safety Administration to investigate to determine whether a defect in the Prius contributed to the crash.
Cortical cell lengths were assessed to determine if a defect in cell elongation also contributed to the root growth defect in exocyst mutants.
We investigated a cohort of 52 patients with combined respiratory chain deficiency without causative mitochondrial DNA mutations, rearrangements or depletion, to determine whether a defect in mitochondrial translation defines the pathomechanism of their clinical disease.
Therefore to determine whether a defect in subunit E3 of the enzyme complex, which is also shared with pyruvate dehydrogenase and ketoacid dehydrogenase complexes, was responsible, the reactions representing the latter were also restricted.
To determine if a defect in ribosome biogenesis was causing the delay at G2/M and the concomitant reduction in cell proliferation rates, the processing of precursor 45S rRNA to its mature forms was examined using pulse-chase metabolic labeling.
Future work to elucidate the mechanisms leading to the read-through transcription, mis-splicing, and loss of polyadenylation that create these fusions is also warranted to determine whether a defect in the regulation of these processes is responsible for these aberrant transcripts.
An important component to this hypothesis is that low insulin-mediated fetal growth in utero is determined by a defect in glucose sensing by the pancreas due to GCK mutations, resulting in reduced insulin levels during critical periods of growth and development of the fetus.
