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Subsequent CD4 determinations performed before the time indicated by the rule (tnext) were counted, compared with the threshold, and discarded as superfluous.
In the data collected, the number of patients with aPL determinations performed before or at the time of kidney transplantation was low; therefore the association between these antibodies and the thrombotic complications was weak and not significant.
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The determination of MTX serum levels was performed before and immediately after the end of drug infusion, and repeated every 24 h until the MTX serum concentration fell under the threshold concentration of 0.05 μmol l−1.
The ultrasound and AFP determinations were performed before the enrolment and especially before drawing the blood samples in all subjects.
The determinations were performed before disconnection from mechanical ventilation, 30 min after disconnection and 4 6 hours after disconnection.
All determinations performed in triplicate.
For each patient, three serial serum CA15-3 determinations performed at 6 9 months (270 ± 102 days), 3 6 months (139 ± 79 days), and 0 3 months (20 ± 30 days) before PETCT were recovered from the SDN archives.
Binding region overlap determination was performed before and after peaks were compared to gene expression profiles.
CTC determination was performed before individual chemotherapy or hormonal treatment, depending on the pretreatment.
In the German neoadjuvant trial 'GeparQuattro' [ 93], CTC determinations have been performed before and after primary systemic chemotherapy.
Our sequence determination was independently performed before the release date of the data from other groups; the data from the additional 16 species were deposited to the database on May 31 , 2007
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