Urine osmolality was calculated either as salt osmolality (i.e., the part of osmolality exerted by strong ions) and, for the subset of patients in whom urinary nitrogen determinations were available, as total urinary osmolality.
Both plasma and P. falciparum determinations were available for 176 (93%) of these children, 87 (49%) corresponding to the viral group and 89 (51%) to the invasive bacterial one.
A mean of 7.4 glucose determinations were available per patient.
In the current series, aPL determinations were available in 19 patients, because the systematic screening in the renal transplant unit was carried out only in recent years.
Baseline demographic and clinical characteristics of patients with a MACE and patients without an event are represented in table 1 and table 2. A mean of 7.4 glucose determinations were available per patient.
a) No determinations were available before beginning of treatment since this variable requires a disease event b) No cut-off value could be used due to the method's qualitative nature Finally, when taking in consideration all determinations, the 3 methods seemed to behave similarly (table 4), again, with slightly better raw data performance observed for the pp67 mRNA assay.
HIV DNA, CD4 count and plasma viraemia were available from all 219 patients at T0 and T1, and in 86 subjects at T2, while tropism determinations were available from 109 subjects at T0, 219 at T1, and from 86 subjects at T2.
To date various methods for BRS determination are available which differ considerably in specificity, sensitivity and clinical applicability.
Although a variety of methods for BRS determination are available, all of them are hampered either by their invasiveness, low specificity or by methodological limitations.
