Variability in cholesterol measurements frequently renders the interpretation of single or repeated cholesterol determinations problematic, complicating employee counseling within screening programs.
Recruits should be limited to young individuals, but age determination is problematic.
The rampant use of these reagents for such determination is problematic, to say the least, since it is clear that precipitating minerals bind to serum proteins present in the culture medium, casting doubt as what epitopes exactly, not to mention their species origin, the antibodies are really binding to.
The taxonomy of Mastomys is considered unresolved, and species determination remains problematic; 8 distinct species are recognized, and several coexist in Lassa fever endemic areas (5 ).
If indexing or space-group determination is problematic, it may be worthwhile to process the data assuming a triclinic P Bravais lattice and then do a careful search for valid unit cells with higher metric symmetry followed by thorough examination of systematic absences to choose the correct space group, which will necessitate reprocessing of the data.
That type of device will give remediators the ability to determine when a treatment has been adequately completed, currently a problematic determination to make.
The use of Acoustic Emission (AE) signal of scratch test to evaluate the thin films' adherence led to unavoidable large uncertainties due to the problematic determination of the frequency band and the improper installation of the acoustic sensor, especially for coatings thinner than 100 μm.
An important feature of the algorithm is its quantitative estimation of the resulting data precision and thus determination of the problematic fragments in raw data.
An important feature of the algorithm is the possibility of a quantitative estimation of the resulting data precision and, thus, determination of the problematic fragments in initial data without operator intervention.
Another difficulty is the complexity of the fragmentation patterns of cross-linked peptides, which makes the tandem MS-based structural determination to be problematic.
