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These results are consistent with the hypothesis that sex-specific selection acts on alleles linked to the male-determining locus driving evolutionary turnover in the sex determination pathway.
We find that the PcG/Trx-G proteins genetically interact with mutations in the sex determination pathway and influence the ability of females to determine their sex.
Recently, the nematode sex determination pathway was also implicated in vulval fate determination [55].
However, the Drosophila sex determination pathway is only partially conserved and the family Tephritidae affords an interesting example.
Identification of several new players in the sex determination pathway [38] indicates that there is lot more to explore in terms of the actual role of the SRY gene.
fruitless is a key component of the sex determination pathway encoding sex-specific and non-sex-specific proteins that are members of the BTB-Zn finger transcription factor family [42], [71].
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The best-studied example of a developmental process controlled by alternative splicing is the Drosophila melanogaster somatic sex-determination pathway.
These targets could have easily escaped previous genetic screens that identified the known components of the sex-determination pathway based on sex-specific phenotypes.
Thus, the sex-specific expression patterns of CG11737 and blow are governed by genes in the somatic sex-determination pathway downstream of Sxl.
While the sex-determination pathway in Drosophila is well understood, the genes which are regulated by the hierarchy have only begun to be identified.
fru and doublesex are the only known outputs of the sex-determination pathway in the brain, so doublesex-expressing cells may also show dimorphisms.
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