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The X-ray crystallography core laboratory provides the equipment, training, assistance, and technological innovations necessary for determination of structures of proteins and other macromolecules.
The determination of structures by numerical solution of the Schrödinger equation has become a highly developed process entailing use of computers and supercomputers.
Determination of structures and dynamics events of transmembrane proteins is important for the understanding of their function.
The recent determination of structures of caspase-1, caspase-3 and caspase-8, together with biochemical studies, has greatly enhanced our understanding of the structure, function and specificity of these enzymes.
In addition, the computational drug development on Nav channels requires the determination of structures from higher-level organisms, especially mammals.
As shown above computer-assisted structure elucidation using 2D NMR data is quite efficient for the determination of structures of complex natural compounds.
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Determination of structure-function relationships has been a long-standing research topic in structural genomics.
Spectral determination of structure of those compounds was performed by NMR and ESI mass spectroscopy.
There are several reasons for measuring physical properties of foods: engineering process design, determination of structure, and texture.
This approach allows a precise and accurate determination of structure-to-property relationships of thin conversion films.
Our method is an extension of the landmark intensity correlation measurements of Hanbury Brown and Twiss13 to higher than second order, paving the way towards determination of structure and dynamics of matter in regimes where coherent imaging methods have intrinsic limitations14.
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