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In both cases, there is a considerable scattering of experimental data, but limiting functional relations have been obtained that allow practical determination of safety values for mass flow hopper outlet size and slope as a function of the flowability index.
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At the screening visit and at the final visit, blood and urine samples were taken for determination of safety laboratory values including hepatic and renal parameters, electrolytes, total protein, albumin, and glucose, as well as a complete blood count.
The international standard on safety instrumented systems (SISs), IEC 61511/ISA 84, requires the determination of safety integrity levels (SILs) for safety instrumented functions (SIFs) in SISs.
See 21 CFR 860.7 for the evidence used in the determination of safety and effectiveness of a medical device.
EN 1990 — Annex D contains a procedure for the safety analysis of resistance functions, based on First-Order Reliability Methods; this procedure permits the determination of appropriate values (in a semi-probabilistic design concept) of partial safety factors γM on the basis of physical or numerical test results.
The activities were too weak for determination of exact values.
Statistical Analysis: Coefficient of determination of data values.
The determination of reference values is a complex procedure.
For determination of IC50 values, experiments were repeated 4 12 times.
Determination of pharmacokinetic values was accomplished through serial blood sampling.
Determination of cutoff values and their relationship with biochemical recurrence.
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