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To facilitate more reliable cross-species comparisons, complete concentration-response curves for ligands were determined in the same microplate as determination of response to a maximal activator.
Three aspects of neoadjuvant endocrine therapy designs are considered: the determination of response; the assessment of surgical outcomes; and biomarker endpoint analysis.
Standardized uptake value may also be valuable as a biomarker in assessing the tumour grade, for guiding biopsy, and for determination of response to therapy in patients with lymphoma.
Computed tomographic and magnetic resonance imaging scans were the only accepted imaging techniques for the determination of response.
Determination of response assessment was as follows: complete response (CR: ratio = 0), partial response (PR: 0 < ratio < 0.5), stable disease (SD: 0.5 < ratio < 1.25), or PD (ratio > 1.25).
A similar observation may be made concerning the determination of response or lag times, which are highly dependent on the concentrations used.
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For quantitative determination of responses, at least 3 animals were used in each group and the average response obtained.
Proof of principle of the use of transcriptomics for non-model organisms has been demonstrated in determination of responses of e.g. aquatic organisms to toxicants [11], [12] and the identification of geographic sites of origin [13].
These HSEs enable direct determination of phenotypic response of a wounded epithelium including cell proliferation, migration, differentiation, growth-factor response, and protease expression of epithelial and stromal cells.
New insights on the determination of extreme response distribution from random process method are also presented focusing on a better modeling of the response distribution tail.
However, in the presence of a partial metabolic response, both RECIST 1.1 and the revised Cheson criteria maintain the use of tumour size measurements for determination of tumour response (Fig. 3).
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calculation of response
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judgment of response
setting of response
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clarity of response
determination of responsiveness
verification of response
choice of response
selection of response
confirmation of response
determination of interventions
set of response
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