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We chose the ToppGene suite for determination of pathways enriched in the genetic interactomes.
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Investigations of both pathway activation and blockade of signal transduction are necessary for the determination of pathway-specific effects, and the readouts should focus on all pathways relevant for normal lung development and lung injury to get a comprehensive view on BPD.
Determination of axonal pathways provides an invaluable means to study the connectivity of human brain and its functional network.
For the determination of metabolic pathways, mass spectrometry turned out to be one of the most powerful techniques for the detection of all types of low-molecular weight metabolites even on systems level [ 1– 3].
Because the mechanisms involved in infection-induced thymic atrophy are not completely understood and may vary depending on the microorganism, the determination of specific pathways in distinct situations is essential to define strategies for preventing thymic atrophy and/or promoting the recovery of thymic function once the infection is controlled.
The applications discussed include a homogeneous assay to screen for compounds binding the taxol site, the determination of the pathway of taxol entry into microtubules and the design of high affinity microtubule-stabilizing agents.
The loci are obtained from the determination of regulatory pathway.
GO relies on human curated annotations for determination of each pathway.
Some of the tissues were lysed for protein isolation and then processed for the determination of signaling pathway proteins using Western blot method.
Sixty-seven HER2-positive metastatic breast cancer patients were recruited into a global lapatinib Expanded Access Program and 57 patients have primary tumor specimens available for determination of PI3K pathway status.
(18) For example, nontargeted metabolomic approaches can provide an unbiased determination of metabolic pathway perturbations in response to toxicant exposure and can lead to determination of toxicant mode of action.
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