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As part of our ongoing research in the synthesis of new heterocyclic compounds containing a thiophene core (Scheme 1), we describe herein the synthesis, characterization, and X-ray structure determination of novel thiophene-containing compounds.
The determination of novel mutations in PRNP remains of major importance for the following reasons.
Therefore determination of novel mutations in PRNP remains of major importance.
This analysis employed programs that offer rapid and robust orthology determination of novel, short sequences from plant ESTs based on reference seed plant genomes.
Such studies would be of clear importance for drug discovery and for the determination of novel therapeutic targets in OA.
Indeed, knowledge of haplotypes across several HLA genes has been shown to generate improved transplantation outcome predictions [ 19, 20] and can therefore facilitate determination of novel haplotype patterns for drug discovery and genome-wide association studies [ 21].
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A new, simple, rapid, and inexpensive voltammetric method for the determination of a novel fungicide, fludioxonil (Flu), was firstly developed using square wave voltammetry (SWV).
A simple, selective, and sensitive electroanalytical method for the determination of a novel fungicide, fenfuram (Fnf), on a bare boron-doped diamond electrode (BDDE) using square-wave voltammetry (SWV) was developed.
Structure determination of a novel macromolecular complex via single-particle electron microscopy depends upon overcoming the challenge of establishing a reliable 3-D reconstruction using only 2-D images.
A highly selective, sensitive, and rapid microemulsion liquid chromatography (MELC) method was developed and validated for the simultaneous determination of a novel type of dopamine receptor antagonist LE300 and its N-methyl metabolite in mouse sera.
Chromophor and fluorophor addition reactions involving phenylisothiocyanate (PITC) and dansyl chloride (DC) were optimized to adapt two high-performance liquid chromatography (HPLC) procedures designed for the accurate determination of the novel antitumoral agent ES-285 in Beagle dog plasma.
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