However, although medications were open label, determination of endpoints was blinded and conducted by expert committees.
Development and publication of appropriate experimental analyses (e.g., pharmacodynamic determinations, functional imaging) to capture detailed phenotypic information assists rational determination of endpoints.
Determination of endpoints of IBD segments is difficult, because a small number of genotyped markers may be consistent with IBD beyond the true end of the IBD segment, leading to false extension of the detected IBD segment.
Until now, some progress has been made in the determination of endpoints suitable for determination of embryotoxicity in differentiating hESCs, and proof-of-concept was provided that hESC-based in vitro systems may be useful to predict human-specific developmental toxicity.
A pre-determination of endpoint(s) to be defined is critical during planning of resistance assays.
Ideally, scores should be independent of clinician determined therapeutic variables, to minimize bias in the determination of the endpoint [ 4].
However, the optimal duration of follow-up for the determination of mortality endpoint in such trials is uncertain.
The best-observed response was taken as a basis for the determination of primary endpoint and confirmed responses were also reported.
The design of remediation strategies and the determination of remediation endpoints are traditionally carried out without quantifying risks associated with the failure of such efforts.
