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After determination of compound overlap, machine learning approaches were used to establish multi-label classification models for BCRP/P-gp.
X-Ray single crystal structure determination of compound 4a and 5a also confirmed the structure of the products (Figure 1a and b).
With the exception of clenhexyl, procaterol, and reproterol all LOQs enable determination of compound concentrations at the MRPL level.
Although X-ray structure determination of compound 24[A] was not successful, the molecular structure is confirmed by spectroscopic data and computational investigations.
Quantitative determination of compound 3 within the formulations allowed us to apply the same doses in each case, as expressed in compound 3 equivalents.
Blood was collected, (via cardiac puncture), processed for CBC, or processed to plasma and frozen on dry ice and stored at -80°C until determination of compound levels.
Similar(52)
The method was satisfactorily applied for the determination of compounds in human placental tissue samples collected at delivery from 25 randomly selected women.
Most procedures for the determination of compounds by MLC make use of micellar mobile phases containing an organic modifier (hybrid micellar mobile phases), which is usually a short-chain alcohol (methanol, propanol, butanol or pentanol) or acetonitrile.
A novel alternative for the simultaneous determination of compounds with similar structure is described, using the whole chemiluminescence-time profiles, acquired by the stopped-flow technique, in combination with mathematical treatments of multivariate calibration.
Bioassay-driven purification and structural determination of compounds from plant sources have yielded a number of pump inhibitors which acted against gram positive bacteria.
Bioassay driven purification and structural determination of compounds from various plant sources yielded a number of EPIs acting against Gram- positive bacteria with activities similar to 5'-MHC [11], [12], [13], [14], [15], [16].
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