At the beginning of therapy and after it ended, all patients underwent blood chemical tests, anthropometrical measures, determination of body composition by bioelectrical impedance, spirometry, and indirect calorimetry.
Following the determination of body composition, obese participants (BMI >30 kg/m2) were selected based on the Canadian guidelines for body weight classification in adults [16] and were separated in the following two groups: a control group (without any intervention; n = 12) and a training group (n = 12).
Determination of body composition using Dual-Energy X-ray Absorptiometry (Figure 1B) showed that M-P mice had a significant increase of their fat mass (43.5%) compared to PBS- or IL-7-treated animals (16% and 19.3%, respectively).
Similarly, determination of body composition is an integral component of the workup of patients with kidney disease at our institution.
BIA technology has been shown previously to provide accurate determination of body composition in various stages of CKD, including patients undergoing maintenance hemodialysis [ 30– 30].
With greater awareness and more detailed clinical studies including laboratory testing and determination of body composition, it will become evident whether this phenotype is a circumscribed entity.
