To date various methods for BRS determination are available which differ considerably in specificity, sensitivity and clinical applicability.
Although a variety of methods for BRS determination are available, all of them are hampered either by their invasiveness, low specificity or by methodological limitations.
HLA class I antigen determination was available in this group.
Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) determination were available for 12 patients.
Useful hints about Ct determination are available from real-time PCR manufacturers.
Finally, at the last available visit (after the coronary event), LDL-cholesterol determination was available for 73% of patients, and in 41% it was >100 mg/dL.
At the time of the coronary event, an LDL-cholesterol determination was available for 47% of patients, and it was >100 mg/dL in 45% of them.
The only exception among patients with disease was patient J, that showed negative determinations 15 days before the onset of clinical disease, and no latter determination was available before disease was observed.
Genotype determination was available in 44 (42 %) patients with SS: 30 (70 %) patients had genotype 1b, eight (19 %) genotype 1a, and the remaining five (11%%) non-1 genotypes, including genotypes 2 (n=1), 3 (n=2), and 4 (n=2); in one sample, HCV was not genotypable by the molecular assay.
For many rate coefficients, a large number of experimental and theoretical determinations are available, and a normal distribution can be assumed for the uncertainty of ln k.
