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We also assessed the representativeness of the study participants; methods for ascertaining exposure; comparability of exposure groups (including unexposed) in terms of age, sex, socioeconomic status, non-response bias, health outcomes, determination, and validation of outcomes; internal validity; and assessment and addressing of confounding factors.
The laboratory results coupled with ABAQUS/Explicit simulations provided a tool for determination and validation of the models' parameters for each material.
Planning orthognathic surgery requires the determination and validation of correct mentolabial morphological relationships, which requires two sources of information [10].
For β-TrCP knockdown determination and validation studies 2 µg of RNA were used as template for synthesis of cDNA using SuperScript™ II Reverse Transcriptase.
For the determination and validation of the quasi-monomorphic variation range (QMVR) for each of the five MSI markers, PCR amplification profiles were scored individually, and the size of both alleles was determined for each marker and for each tumor individually as described previously [11].
Distributional form of the raw-scale predictions (determination and validation) were displayed using violin plots.
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Predictor variables for hospital mortality were analysed using logistic regression with cross-validation (80% determination and 20% validation) and robust, cluster-specific (ICU site) standard errors.
The BiomarCaRE project is designed as a multi-modular study including: (1) biomarker selection based on omics discovery studies as well as literature, and (2) assay development (Module 1), (3) data harmonization of large-scale studies and (4) biomarker determination, analyses and validation (Module 2), and (5) biomarker assessment in clinical trials and (6) economic evaluation (Module 3).
Gene expression analysis was performed using a Mouse Multiple Sclerosis RT² Profiler PCR Array, and further determinations and validations of the identified genes were performed using qPCR.
It is composed of three different steps: feasibility analysis, pre-design determination and simulation validation.
We used ArcView GIS (version 8.3) and its Geostatistical Analyst Extension (ESRI Inc., Redlands, CA) for semivariogram determination and cross-validation and for subsequent spatial estimation of daily location-specific PM concentrations.
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