Hence, we have provided substantial support for the viability of the goal of structural genomics, i.e., reducing the number of functionally uncharacterized proteins through structure determination and function prediction.
Despite the significant importance of discontinuous domains in protein structural determination and function annotations, there is so far no efficient method available for discontinuous domain prediction.
Identification of these protein disorder regions is important for protein production, protein structure prediction and determination, and protein function annotation.
At CAT, we take a multidisciplinary approach in the investigation of natural toxins that includes isolation and purification, studies of pharmacological actions, toxin structural determination, and structure-function studies and its molecular biology aspects.
In this high throughput sequencing era, determination of structure and function of proteins cannot match the rate of incoming sequence information.
Identification and characterization of ergM showed that this is a gene fundamental to cell wall maintenance, nutrient uptake, and polarity determination, and loss of function results in severe growth defects in P. marneffei and important differences in susceptibility to antifungal agents.
In winter, the sentinel GPs are asked to take nose and/or throat swabs from patients with ILI for virological determination and these data function as the official data on which national and international decisions by health policy-makers are based.
The clustering of all members into well-defined subfamilies and detailed analysis of features characteristic for these subfamilies will help to select representatives for the experimental determination of function and structure and will facilitate the classification of novel members identified in the future.
Studies of sex determination genes – their history and function – in non-model insects and Drosophila have allowed us to begin to understand the generation of sex determination diversity.
In 1951, when the American biologist James Watson arrived at the laboratory, it was known that the mysterious nucleic acids, especially DNA, played a central role in the hereditary determination of the structure and function of each cell.
Furthermore, no 3D structure has been reported for any MSP, so the determination of the structure and function of MSPs is an interesting and important task.
