In contrast, the advances in genome-wide profiling technologies open the possibility of genome-wide scans for genetic determinants responsible for drug response.
Regardless, further work is still needed to characterize the protective response(s) elicited by vaccination with attenuated mutants of type A or type B F. tularensis, and define the antigenic determinants responsible for stimulating this response.
To determine the underlying genetic determinants responsible for SS3's enhanced xylose utilization and ethanol productivity, we used next-generation sequencing (NGS) technologies to identify the potential genetic changes in SS3 as well as SS17 and SS18.
Abiotic stresses, such as water deficit and soil salinity, result in changes in physiology, nutrient use, and vegetative growth in vines, and ultimately, yield and flavor in berries of wine grape, Vitis vinifera L. Large-scale expressed sequence tags (ESTs) were generated, curated, and analyzed to identify major genetic determinants responsible for stress-adaptive responses.
Our data indicated that, while the growth rates of NY99 and chimeric viruses in tissue culture are determined primarily by properties of the structural proteins, determinants responsible for a highly cytopathic phenotype of NY99 or lack thereof for W956 are located within the nonstructural protein region of the WN genome.
Consequently, the precise molecular determinants responsible for melanoma progression are yet to be delineated.
To gain insight into the determinants responsible for the broad cytolytic activities, two analogues of cupiennin 1a with different N-terminal hydrophobicities were designed.
Further, the crystal structure of ECAI forms a basis for indentifying molecular determinants responsible for isomerization of arabinose to ribulose in vivo and galactose to tagatose in vitro.
We show here that the homeodomains encoded by the Ultrabithorax and Deformed homeotic genes bind optimally to distinct DNA sequences and have mapped the determinants responsible for differential recognition.
These results encouraged us to further explore the structural determinants responsible for the activity of this class of HDAC inhibitors in order to gain guidelines for the rational design of new derivatives with putative higher affinity for this target.
Identification of the epitopes recognized by these neutralizing antibodies will provide insight into the antigenic determinants responsible for eliciting neutralizing antibodies in vivo that can be used in the design of effective vaccine strategies.
