Exact(2)
Assessment of the specific quantitative impact of these two determinants requires information on both the stage at diagnosis and of different treatment regimens among cases.
Identification of environmental determinants requires frequent follow-up for autoantibody testing and a large number of individuals from early in life until disease onset for studying a variety of exposures using epidemiological and laboratory methodologies.
Similar(58)
A library of alanine substitutions in α was used to identify the αCTD determinants required for Fis-dependent transcription at rrnB P1 and rrnE P1.
The full-length hepatitis C virus (HCV) JFH1 genome (genotype 2a) produces moderate titers of infectious particles in cell culture but the optimal determinants required for virion production are unclear.
Identifying the structural determinants required for receptor binding of Bv8 PKs is mandatory for the design of PKR antagonists, which may be useful in the treatment and prevention of various disease states.
To initiate the analysis of structural determinants required for FTCD function in vimentin dynamics, we used structure-based design to generate individual formiminotransferase (FT) and cyclodeaminase (CD) domains, and to produce an enzymatically inactive FTCD.
Functional determinants required for allosteric control identify: (i) an important link between the ATP bound ribose moiety and the SensorII motif that would allow nucleotide-dependent α-helical α/β subdomain dynamics; and (ii) establishes a novel regulatory role for the SensorII helix in PspF, which may apply to other AAA+ proteins.
To enable automated inference, this study establishes (1) a work condition ontology that consists of the determinants required to select work items, (2) a work item ontology, which consists of the factors defining the tiling method, and (3) semantic reasoning rules.
These data suggest that the determinants required for CFH binding are defined by conformation rather than contiguous linear elements.
Taken together these results indicate that IntI1 possesses all the determinants required for the attC recombination reaction and that the bsattC intermediate can be generated during the reaction time in absence of other protein in addition to the recombinase.
Most of the variants did interact with hCG1, UNG2 and DCAF1, as visualized by growth of yeast-transformed cells on medium without histidine (Fig. 3), arguing for a good conservation of the structural determinants required for Vpr functions.
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