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Structural determinants required for the bioactivities of prokineticins and identification of prokineticin receptor antagonists.
Mutational studies of the IZUMO1 JUNO interface by both groups reveal the structural determinants required for binding.
Cummings, R.D. & Kornfeld, S. Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins.
A library of alanine substitutions in α was used to identify the αCTD determinants required for Fis-dependent transcription at rrnB P1 and rrnE P1.
The full-length hepatitis C virus (HCV) JFH1 genome (genotype 2a) produces moderate titers of infectious particles in cell culture but the optimal determinants required for virion production are unclear.
Identifying the structural determinants required for receptor binding of Bv8 PKs is mandatory for the design of PKR antagonists, which may be useful in the treatment and prevention of various disease states.
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The cellular and molecular determinants require further investigation.
Assessment of the specific quantitative impact of these two determinants requires information on both the stage at diagnosis and of different treatment regimens among cases.
Identification of environmental determinants requires frequent follow-up for autoantibody testing and a large number of individuals from early in life until disease onset for studying a variety of exposures using epidemiological and laboratory methodologies.
We show here that the coordinated orientation of individual progenitor cell division in the neural keel is the cellular determinant required for morphogenesis into a neural tube epithelium with a single straight lumen.
Also, our mutational studies suggest that the structural determinant required for ciliary D1R targeting is a relatively extended structure.
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