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A main advantage of the subunit approach is that the ideal vaccine will induce immune responses against only those determinants relevant to protection, thus minimizing the possibility of deleterious responses.
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These determinants are relevant to the relationship between ongoing exposures and endpoints resulting from chronic exposure (i.e. cardiovascular disease) but would not be as applicable to circumstances associated with the population consisting of women of child bearing age.
The consistency of our findings with those for general health suggests that the mechanisms linking general health and broad social determinants are also relevant to oral health.
The data were then further coded in relation to the specific dimensions of supply and demand-side determinants of access relevant to the framework (figure 1) 11 and by ICDP measures (table 1).
It is also possible that there are other structural determinants of equity relevant to maternal and reproductive health in India but these have not been studied and/or published in peer-reviewed journals.
The choice of the determinants, relevant for this multivariate analysis was based on literature [ 4, 19, 20].
The heterogeneous nature of this frail population requires that program and policy makers clearly understand the determinants of multi-dimensional indices of health [ 4] and appreciate the potential for sex-differences in these determinants relevant for targeted or individualized care planning.
Inclusion criteria included: (a) the paper was available in English, (b) the paper focused on HIV or a recognized determinant and/or behavior directly relevant to HIV transmission (e.g. injecting drug use, sex work) and, (c) the paper focused on Indigenous peoples.
6 Both the diversity (The term 'diversity' describes the dissimilarities between host and migrant populations relevant to the determinants of health (such as genetics and biology, environment, behavior, and socioeconomics);'disparity' reflects the burden of inequalities present at both individual and societal levels, which affects the determinants of health).
Additional genetic correlation analyses suggest the presence of a set of genetic determinants that are likely to be relevant to multiple phenotypic traits.
Marmot and colleagues work in this area has highlighted the vast individual and group level differences in health outcomes driven by disparities across these various determinants [ 6– 8]—facthat thareare particularly relevant to Indigenous peoples.
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