Although family studies suggest that environmental factors are the major determinants of variance in chronic periodontitis [ 1- 5], comparisons between reared-together and -apart adult monozygous twins indicate that early family environment has no appreciable influence on periodontal status of adults [ 6].
Importantly, the simulations showed that the distribution of "quality traits" among males and the ability of females to distinguish between males of different "quality" were the strongest determinants of variance; male "quality trait" values were interpreted to summarize attractiveness based on all possible mate choice cues including the males' territories (Sefc, 2008).
Importantly, principal variance component analysis confirmed that the largest determinant of variance came from tissue source (LPLs vs blood vs IELs) with cell type (CD4+ vs CD8+) showing less contribution, and interindividual variation accounting for <5% of total variance (figure 1A), an observation borne out by unsupervised hierarchical clustering analysis (figure 1B).
We find HCE as well as GDP to be significant determinants of the variance of health status.
Subsequently, because LASSO can over penalize highly collinear variables, we then performed an ordinary least squares (OLS) best model multiple regression on the subset of selected variables/features taken from LASSO to obtain beta estimates, regression coefficients, and determinants of explained variance.
However, patient characteristics, such as health conditions, explained only 4% of this variance (Table 3), suggesting that the main determinants of variability were unmeasured.
Post-exercise REE data from the current study eludes to exercise intensity, instead of duration, as the primary determinant of EPOC variance, similar to several studies [4-6].
The D-optimal design approach iteratively updates a set of sample configurations in order to increase the determinant |H T ·H|, i.e., minimize the log-determinant of noise variance matrix in (15) to find optimal sample configurations.
The designs proposed in this paper minimize the log determinant of the variance of the estimated treatment effects over all possible allocation of the n subjects to the treatment sequences.
Moreover, epistasis is a major determinant of phenotypic variance for host resistance.
Overall, our results suggested that epistasis is a major determinant of phenotypic variance for isoflavone seed contents, and that many small individual interactions contribute to the total effect.
