The multivariate model kept CHIKV infection, comorbidity and acute stage depressed mood as independent prognostic factors for both arthralgia and arthritis, but found early chronic stage RD as the main determinant of the same RD two years later.
Strengths and novelties of the study include the joint comparison of regional and individual determinants within the same small country taking advantage of two distinct socio-cultural regions of similar size and with a similar climate.
The pattern of significant determinants remained the same.
These results demonstrate two levels of diversity in the binding sites on ankyrin: one resulting from different combinations of ANK repeat domains and another from different determinants within the same combination of repeat domains.
Because the mathematical relationships between SvO2 and its determinants are linear (VO2 and SaO2) or curvilinear (haemoglobin and CO), the weight of these determinants is not the same; the influence of VO2 and SaO2 is independent of their absolute values, but a small decrease in CO in a hyperdynamic state does not induce any change in SvO2.
It is not yet clear whether the association of multidrug-resistance and clones results primarily from the spread of already established MDR strains, or rather from independent acquisition of resistance determinants by susceptible strains of the same clone.
Given that one study demonstrated that trichostatin A blocks azole-induced upregulation of resistance determinants in C. albicans (Smith and Edlind, 2002), we measured transcript levels of the same resistance determinants, including key multidrug transporters and the azole target ERG11.
Though now genetically mixed to varying extent, our study population is likely to have the same genetic determinants of the glaucoma seen in those populations.
In a second model, we assessed the determinants of CBF among the same parameters as above (MAP, Sepsis, NE infusion, and interaction between MAP and T100 mmHg).
Here we used a subset of the data used in our previous work (Josse, Seghier, Kherif, & Price, 2008; Seghier & Price, 2011) that investigated the condition dependent determinants of lateralization in the same three vOT subregions we investigate here.
