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We next broadened our analysis and sought to characterise more generally the determinants of the expression of TSG not limited to miRNA.
Carotenoid acquisition and accumulation are key determinants of the expression of male sexually selected carotenoid-based coloration and a primary mechanism maintaining the honest information content of these signals.
In order to identify genetic determinants of the expression of the UGT genes found to be associated with MD, we performed eQTL analyses of SNPs in these genes as available from an array based GWAS study and a candidate gene study.
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This indicates that GacSGacA is the sole determinant of the expression of the genes of the hrp regulon and that ectopic expression of other components cannot initiate or sustain the expression of the regulon.
The clustering demonstrated that in the hypothalamus, social rank (and, consequently, aggressiveness) was a greater determinant of the expression of the chosen gene set than sex (Fig. 5Ai).
The results also highlight the role of TP53 as a determinant of the expression profile and as an important prognostic marker of breast cancer.
Tissue type and cell composition appear to be a larger determinant of the expression profile of such transcripts than the individual from which the tissues were obtained.
These data demonstrate that Map3k4 haploinsufficiency is the cause of T-associated sex reversal and that levels of this signalling molecule are a major determinant of the expression profile of Sry.
Hierarchical clustering and PCAs of these data on day 5 (Fig. 6B), analogous to those performed on the data for day 1 (Fig. 5A), demonstrated that social rank was no longer the main determinant of the expression of the study gene set; rather sex was more important.
This SMC hyperplasia (arterioles) or hypertrophy (conduit arteries) requires a shift from the resting to the activated phenotype (Scholz et al, 2000; Davis-Dusenbery et al, 2011) which is characterized, for example, by a decline in myocardin, a pivotal determinant of the expression of SMC marker proteins (Pipes et al, 2006; Parmacek, 2007; Pfisterer et al, 2012).
In this report, we collected the transcriptome and proteome data measured under heat stress condition from recently published literature and studied the sequence determinants for the expression level of heat-responsive genes on multiple layers.
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