Sentence examples for determinants of target from inspiring English sources

There is evidence that proto-spacer-adjacent motifs are determinants of target recognition [ 13, 20].

The latter observation emphasises the need to further define these apparently un-conserved determinants of target specificity [ 35, 36] if we are to extend our knowledge beyond that of the critical seed region.

Bicoid concentration and affinity to regulatory chromatin elements are important (but not the sole [ Ochoa-Espinosa et al., 2009; Chen et al., 2012]) determinants of target gene expression along the anterior-posterior axis of the Drosophila embryo (Driever et al., 1989; Burz et al., 1998).

Target interaction does not require perfect complementarity between microRNA and mRNA sequences, although near-perfect base pairing in a small region in the 5′-end (positions 2 8) of the miRNA (sometimes termed "seed") appears to be one of the key determinants of target recognition [ 4].

For each position 15 nt upstream and downstream of a target site, and for 1 15 nt windows beginning at each position, the partial correlation of the log10 unpaired probability) to the log2 mRNA fold change) associated with the site was plotted, controlling for known determinants of targeting used in the context+ model, which include min_dist, local_AU, 3P_score, SPS, and TA (Garcia et al., 2011).

10 Given the potential role of social support in perinatal depression, the potential influence of family structure on social support, and the lack of evidence on family structures outside Western settings, there is a clear need for further research in this area, as these issues are likely to be important determinants of targets for intervention strategies.

The seven or eight nucleotides at the 5' end of a miRNA that has been postulated to serve as the primary determinant of target specificity.

The ability to briskly activate MAPK signaling in response to bacterial PFT is a critical determinant of target cell survival [4], and downstream signaling, including activation of the unfolded protein response, has been shown to mediate such survival [5].

Typically, positions 2 7 from the 5' end are considered to be the primary (canonical) determinant of target specificity [ 34– 34].

A seed region of about 7 nucleotides in length at the 5' end of an animal miRNA is thought to be an important determinant of target specificity [ 23].

The seed sequence of a miRNA is the major determinant of target specificity and represents the functional entity of a miRNA.