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Several reports indicate that an increased gene copy number of EGFR or mutations of genes responsible for downstream signalling, especially KRAS, are important determinants of response or resistance to anti-EGR antibodies (Heinemann et al, 2009).
Fraietta, J. A. et al. Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia.
Presentation will provide clinical trial data on time to response and determinants of response to antidepressant treatment.
With the goal of identifying determinants of response, we performed molecular characterization of tissues and circulating tumor DNA (ctDNA) from 61 patients with mGC who were treated with pembrolizumab as salvage treatment in a prospective phase 2 clinical trial.
A better understanding of the determinants of response to antiangiogenic agents and their mechanisms of action, especially in combination with cytotoxic drugs, is crucial to future drug development.
Pharmacogenetic approaches will be needed to identify individual determinants of response and outcome in order to maximise the benefits of targeting specific molecular events and keep side-effects to a minimum.
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Further investigations confirmed the importance of viral passage in its pathogenicity, because we determined the characteristics and lineage of the virus to be important determinants of responses.
These results suggest that both context and type of enrichment are important determinants of responses to enrichment.
The timing and the previous activation status are major determinants of responses that cytokines elicit.
This contrast in perspectives suggests that epistemological beliefs, from which expectations arise, are important determinants of responses to uncertainty.
Logistic regressions were used to explore determinants of responses in the EQ-5D dimensions, and robust linear regression was used to explore determinants of the EQ-5D index.
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CEO of Professional Science Editing for Scientists @ prosciediting.com