Sentence examples for determinants of recombination from inspiring English sources
This raises the interesting possibility of DNA sequence and/or other cis- elements as determinants of recombination.
Based on these findings, we propose G4 DNA could be one of the determinants of recombination wherein the single-stranded fold back structure could assist in strand separation and homologous pairing.
The approach can achieve very fine scale resolution, unmasking genomic features and leading to the discovery of determinants of recombination rate variation.
Of course one of the most recent, well-studied determinants of recombination, Prdm9, is absent in Drosophila, just one of many other differences that set Drosophila recombination apart from other organisms.
Our results provide evidence in a multicellular organism that transcription during the initial phases of meiosis increases the likelihood of DSB and give insight into the molecular determinants of recombination rate variation across the D. melanogaster genome.
These results provide insight into the molecular determinants of recombination rate variation across the D. melanogaster genome and a clear path for future studies to assess the molecular causes of recombination variation among individuals and its plastic nature.
By using T cell receptor beta substrates that integrate stably into nuclear chromatin, we show that promoter location, rather than germ-line transcription or histone acetylation, is a primary determinant of recombination efficiency.
A result further supported by the studies conducted on the fast-evolving DNA-binding domain of PRDM9, identified as a major hotspot determinant of recombination.
The human protein PRDM9 has recently been identified as a major determinant of recombination hot spots in human (Baudat et al. 2010; Berg et al. 2010; Myers et al. 2010; Parvanov et al. 2010).
Although the connection between PRDM9 and recombination hotspots is not perfect (Myers et al. 2008; Berg et al. 2010), approximately 40% of hotspots in the human genome contain this motif which remains, so far, one of the very few known determinants of meiotic recombination.
