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Indeed, knee alignment is one of the key determinants of load distribution [ 5], and knee medial bone marrow lesions are more likely in OA patients with varus knee alignment, whereas lateral bone marrow lesions are more common in those with valgus alignment [ 6].
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According to the achievements in ulcer prevention techniques (Oomens et al. 2003; Ragan et al. 2002), the above-mentioned determinants of loading, i.e., shear and pressure, should not be analyzed as separate criteria, as this can lead to misinterpretation of findings.
A key determinant of LOAD is aging and, in fact, many, if not all, pathological events in LOAD are also part of the normal aging process.
Knee malalignment is a determinant of load distribution, and is associated with OA progression [ 4].
We evaluated the inter-annual variation and distribution of burned areas, and used linear models to explain this variation in terms of rainfall amount (determinant of fuel load production), seasonal rainfall distribution (determinant of dry fuel availability), abnormality of precipitation (Standardized Precipitation Index – SPI), and vegetation type (Enhanced Vegetation Index – EVI).
Biomechanically, changes in varus-valgus alignment of the lower-limb can ameliorate the external knee adductor moment, which is the major determinant of joint load distribution at the knee [ 15].
The fact that average tumor size was not correlated with tumor load, which is the product of average tumor size and tumor number, suggests that tumor number is much more variable than average tumor diameter and is the major determinant of tumor load.
While we detected amyloid-β in vivo with [C]PiB and [F]AV45 binding, we observed discrepancies with ex vivo determinants of amyloid-β load for both these tracers.
In addition, the size of the NLP and the surface area of the lipid bilayer are key determinants of the potential for loading of cargo in or on the NLP bilayer.
We suggest that the number of sexual partners and smoking may be determinants of high HPV viral load rather than determinants of the presence of HPV per se.
Statistical determinants of the post-methionine load increase in homocysteine were identified in multiple linear regression models.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com