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Here, we review and attempt to integrate these local determinants of gene expression.
32 (2004) 936 948; A.C. Hsieh, R. Bo, J. Manola, F. Vazquez, O. Bare, A. Khvorova, S. Scaringe, W.R. Sellers, A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens, Nucleic Acids Res.
Only then large-scale mapping of the determinants of gene expression will become truly informative.
These two factors are potentially important determinants of gene flow through seed exchange or intercrossing.
Expression quantitative trait loci (eQTL) studies have helped identify the genetic determinants of gene expression.
Using this new approach, we identify which genomic traits are significant determinants of gene expression levels and breadths.
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Other relevant determinants of genes' evolutionary rates include the length (Subramanian and Kumar 2004; Ingvarsson 2007) and function (Castillo-Davis et al. 2004; Alvarez-Ponce and McInerney 2011) of the encoded products.
The affinity of transcription factors (TFs) for their target DNA is a critical determinant of gene expression.
As the metabolite-dependent cotranscriptional folding and unfolding dynamics of riboswitches are the key determinant of gene expression, it is important to investigate both the thermodynamics and kinetics of riboswitches both in the presence and absence of metabolite.
However, the linear arrangement of cis-acting regulatory elements is in some context a critical determinant of gene expression.
In D. melanogaster HP1 is known to be a key determinant of gene silencing in the vicinity of heterochromatin blocks [34] and the protein is thought to play a similar role in mammalian cells.
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