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[4], who determined that fear of movement/reinjury are determinants of function after ACLR.
Notably, as this study draws from many previous ideas, such as 3D templates [57], [76] evolutionary importance [35], functional site analysis [88], molecular determinants of function [23], [20] and network analysis [64], [69], [89], [90] it combines them uniquely by repeatedly relying on evolution at each step of the annotation process.
[4] both determined that fear of movement/reinjury are supported as determinants of function after ACLR, neither assessed the influence of relevant impairments routinely assessed in clinical practice (i.e., single-leg hop capabilities, quadriceps strength, and anterior knee joint laxity) in conjunction with fear of movement and reinjury in their patient populations.
[4] both previously determined that fear of movement/reinjury are supported as determinants of function after ACLR, neither assessed the influence of relevant impairments routinely assessed in clinical practice in conjunction with fear of movement and reinjury in their patient populations.
Although patients with advanced disease have well-documented and profound functional limitations, less is known about the determinants of function in early to mid-stage disease where interventions may be more likely to benefit and preserve function.
Organic chemistry has systematically probed the chemical determinants of function in nucleic acids by variation to the nucleobase, sugar ring and backbone moieties to build synthetic genetic polymers.
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Psychological characteristics have been found to be important determinants of functioning in other chronic diseases.
Natural contamination and anthropogenic pollution of soils are likely to be major determinants of functioning and survival of keystone invertebrate taxa.
Cardiac histo-anatomical organization is a major determinant of function.
Shape is an important determinant of function, which is precisely reflected by mitochondrial dynamics.
For multidomain proteins we have tended to use the alignment of the ATPase domain as the determinant of function.
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