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Finally, we investigate whether compliance with the intervention is significantly associated with changes over time in physical condition, muscle strength, HrQOL and fatigue, and also determine possible determinants of effectiveness.
These findings can be distinguished into three topics of special interest, i.e. genetic and other determinants of effectiveness and adverse effects of statins; cardiac rhythm disorders and sudden cardiac death; and miscellaneous pharmaco-epidemiologic topics of interest in the Rotterdam Study.
Previous research on the determinants of effectiveness in knowledge systems seeking to support sustainable development has highlighted the importance of "boundary work" through which research communities organize their relations with other fields of science, other sources of knowledge, and the worlds of action and policymaking.
Previous research on the determinants of effectiveness in knowledge systems seeking to support sustainable development has highlighted the importance of "boundary work" through which research communities organize their relations with new science, other sources of knowledge, and the worlds of action and policymaking.
The controversy is subdued in the case of most effectiveness research, where it is accepted that key determinants of effectiveness, especially treatment adherence, may be influenced by individual preferences independent of the person's biological-clinical or socio-demographic characteristics [4].
Five articles assessing clinical features and five assessing health care system-related features as determinants of effectiveness from January 2010 to October 2014 were included.
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Currently, significant improvement in PFS is a surrogate endpoint accepted as demonstrating clinical benefit of therapy in metastatic RCC patients, and appears to correlate with OS. 39 The ultimate effect on survival however, remains a critical determinant of effectiveness.
The compliance to ECS therapy, a major determinant of effectiveness, was 55.6% after 24 months.
Adequate mental health training for the case manager was found to be a key determinant of effectiveness.
Nevertheless, given some participants' difficulty in interpreting more metaphoric messages, further work is required to test alternative executions and assess whether message novelty, immediacy or salience is the best determinant of effectiveness.
We need better markers of prognosis, determinants of treatment effectiveness, and methods to effectively communicate and implement prognostic information.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com