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In the current study, we investigate the molecular determinants contributing to receptor activation by endogenous ligands.
Biochemical and genetic studies have characterized molecular determinants contributing to alter Hcy metabolism.
These plasmids function as virulence determinants, contributing to pathogenesis of S. enterica, especially during the systemic phase of the disease (Libby et al. 1997; Uzzau et al. 2000).
Due to the absence of an experimental CDK4 structure, the ligand and protein determinants contributing to CDK4 selectivity are poorly understood at present.
However, due to the absence of an experimental ATR structure, the determinants contributing to ATR inhibitors' potency and specificity are not well understood.
Asthma is a complex genetic disease with multiple genetic and environmental determinants contributing to the observed variability in response to common antiasthma therapies.
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This research analyzes how users' city attachment levels and other personal determinants contribute to their uses of urban services.
This dependence upon a combination of extrinsic and intrinsic determinants contributes to distinguish IFs from other fibrous cytoskeletal polymers and is key to their function.
Findings from pre- and post-exercise questionnaires demonstrate that the priority setting exercise was perceived as a fair deliberative process, and that following the deliberation, participants became more likely to agree that a broad number of determinants contribute to their health.
Although a small number of basic amino acid substitutions in V3 may be sufficient for changes in coreceptor preference, combinations of V3 mutations can lead to major loss of entry fitness in culture, unless compensated by mutations in or near V1-V2 in gp120 [14], indicating that complex, discontinuous determinants contribute to X4 coreceptor use, at least on certain cell types [9], [15], [16].
This would imply an underestimation of how lifestyle-related determinants contribute to DM.
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