The spike (S) protein of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is not only responsible for receptor binding, but also a major antigenic determinant capable of inducing protective immunity.
We suggest a novel functional role for DNA methylation in the transcribed region as a key determinant capable of restraining the capacity of a gene to respond to internal/external cues.
Each pattern is called an antigenic determinant, or epitope, and each epitope is capable of reacting with a different lymphocyte receptor.
Recently, a codon frequency index could highlight robust determinants of thermostability capable of discriminating thermophilic from mesophilic genomes (Montanucci et al., 2007).
To determine whether the repetitive DENV2 E determinants displayed on hFliC filaments were capable of BCR crosslinking, we tested them on cells expressing receptors specific for the DENV2 E protein.
Otherwise, the determinant substance renders these foci capable of reducing silver ions to form submicroscopic metallic silver particles bound to the target elements.
The extreme cytoplasmic C-terminal tail constitutes an additional oligomerization determinant since it is itself capable of self-association and its presence enhanced tetramerization of recombinant IP3R1 C-terminal fragments [ 4, 6, 8].
The demonstration that gp41 MPER interactions with IgMa allotypic determinants outside antigen binding pockets are capable of eliciting BCR-proximal activation signals makes the important link between this unusual binding and its potential impact on gp41 MPER-specific humoral responses.
